Adrenalin significantly increases intracranial pressure in hypovolemic cardiac arrest model in male piglets

Methods Twenty-one anesthetized male piglet (with a weight 24.3 ± 1.3 kg) were bled 35% via femoral artery to a mean arterial blood pressure of 25 mm Hg during 15 min. Later piglets were subjected to 8 mins untreated ventricular fibrillation followed by 15 min open-chest CPR. At 9 min of CA piglets received amiodarone 1.0 mg/kg and hypertonic-hyperoncotic solution 4 ml/kg infusion for 20 minutes. At the same time vasopressin 0.4 U/kg was given intravenously to vasopressin group (VAS, n = 9), while adrenalin group received adrenalin 20 μg/kg (ADR, n = 12). Internal defibrillation was attempted from 11 min of CA to achieve restoration of spontaneous circulation (ROSC). Experiment was terminated at 3 hours after resuscitation.